Clinical Requirements for Closed-Loop Control Systems

Clinical requirements for closed-loop control systems.

Closed-loop (CL) therapy systems should be safe, efficacious, and easily manageable for type 1 diabetes mellitus patient use. For the first two clinical requirements, noninferiority and superiority criteria must be determined based on current conventional and intensive therapy outcomes. Current frequencies of hypoglycemia and diabetic ketoacidosis are reviewed and safety expectations for CL the...

Clinical decision support systems: the fascination with closed-loop control.

To the engineer a closed-loop control system refers to using a controller with a feedback loop to control states or outputs of a dynamic system. That dynamic system might be the cruise (speed) control on your automobile, maintaining a patient’s paO 2 with a ventilator, controlling depth of anesthesia with an anesthesia machine, or controlling arterial blood pressure with medications from an IV ...

Closed-loop impulse control of oscillating systems

Mining Weighted Requirements from Closed-Loop Control Models

Specification defects are a major source of ambiguities and errors. We propose a new weighted requirement mining framework to address this problem. We define weighted and parametric weighted signal temporal logic (STL) as the underlying formalism to improve the expressiveness. This also improves convergence of the mining process. We provide some primitive results to show the benefit of the new ...

Open-loop and Closed-loop Optimization of Linear Control Systems

A canonical optimal control problem for linear systems with timevarying coefficients is considered in the class of discrete controls. On the basis of linear programming methods, two primal and two dual methods of constructing optimal open-loop controls are proposed. A method of synthesis of optimal feedback control is described. Results are illustrated by a fourth-order problem; estimates of ef...